O'Leary JG, Goodarzi M, Drayton DL, von Andrian UH : Nature Immunol., 7 : 507-516, 2006
T cell- and B cell-independent adaptive immunity mediated by natural killer cells.
①It is commonly believed that only T lymphocytes and B lymphocytes expressing recombination-dependent antigen-specific receptors mediate contact hypersensitivity responses to haptens.②Here we found that mice devoid of T cells and B cells demonstrated substantial contact hypersensitivity responses to 2,4-dinitrofluorobenzene and oxazolone.③Those responses were adaptive in nature, as they persisted for at least 4 weeks and were elicited only by haptens to which mice were previously sensitized. ④No contact hypersensitivity was induced in mice lacking all lymphocytes, including natural killer cells. ⑤Contact hypersensitivity responses were acquired by such mice after adoptive transfer of natural killer cells from sensitized donors. ⑥Transferable hapten-specific memory resided in a Ly49C-I(+) natural killer subpopulation localized specifically in donor livers.⑦These observations indicate that natural killer cells can mediate long-lived, antigen-specific adaptive recall responses independent of B cells and T cells.
1999年から2004年までハーバード大学医学部のフォンアンドリアン教授のオフィスマネージャーとして，グラントの編集とポスドクと学生のための論文や申請書の作成と編集に関わる． 現在，フリーのライター兼エディターとして，International Piano and Classic Record Review等にクラシック音楽に関する記事の執筆，サイエンスの分野ではグラント申請，論文作成，プレゼンテーションの英文校正や編集を行っている．